The Fellows of the College are some of the brightest and best surgeons in the land and the funding enables them to spend a year working on innovative treatments for medical conditions which affect us all. The fellows who are to be supported are selected by the Fund’s Trustees in discussion with the President and other senior members of the College. Brief descriptions of interim reports submitted by a few of the recent Fellows are as follows:-
Mr Karl Pang MRCS - Role of PCA3 in Prostate Cancer
Prostate cancer (PCa) is the most common cancer in UK men. In 2008 UK, there were 37,000 new cases and 10,170 deaths. Investigating PCa includes performing Prostate-Specific Antigen (PSA) blood test and prostate biopsy. PSA-testing often gives false positive results, leading to unnecessary biopsies, which puts patients at risk of physical/psychological complications. A urinary marker, Prostate Cancer-3 (PCA3) is being utilised to diagnosis PCa. However, its exact function and ability to predict biopsy outcomes is presently unclear. The research aims to explore this. Results would help guide biopsy decisions, enhance early diagnosis and reduce mortality.
Miss Liza Osagie MRCS - “Improving bone formation through stem-cell therapy”
The number of joint replacement procedures cases are exponentially increasing across the UK. A 600% surge in annual knee replacements is projected by 2030; evidence suggests 10% of patients will require revision surgery and a further 25% necessitating a third procedure. In contexts of major bone loss implant fixation is severely impeded resulting in a reduced quality of life. This research will investigate whether stem cells can be treated to increase bone formation; this knowledge can help reduce the number of revision surgeries, costs to the NHS and patient morbidity facilitating an earlier return to function
Miss Michelle Griffin MRCS - Nose Reconstruction using Stem-Cells
Nose defects are caused by trauma, cancer, skin diseases and birth malformations. Currently, nose reconstruction uses the patient’s own tissue from elsewhere in the body. This is painful, has wound-healing complications and patient’s available tissue is limited. We performed the first UK nose reconstruction for a patient with nasal cancer using stem-cells and a unique man-made polymer. We aim to improve our technique in developing nasal constructs by modifying the polymer’s physical and mechanical properties. This will lead to an alternative reconstruction option that overcomes complications with current techniques and can be modified for various nasal defects.